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Morphine

Morphine Sulfate (MS)

CLASS

Analgesic - opium derivative, Schedule II narcotic
Opioid analgesic

DOSAGE

    Adult: 2-10 mg IV slowly. Repeat with small increments every 5 minutes until desired response is achieved Max of 20 mg for pain management (max. 30 mg over 20 min for burns). Can also be given IM or SC.

    Pediatric: 0.1-0.2 mg/kg IV slowly.

    Infant: 0.05-0.1 mg/kg IV slowly.

ACTIONS

    Morphine is a narcotic analgesic, which depresses the central nervous system and sensitivity to pain. Increases venous capacitance, decreases venous return and produces mild peripheral vasodilation. Morphine also decreases myocardial oxygen demand.

INDICATIONS

    - Pain from acute myocardial infarction.
    - Pulmonary edema.
    - Pain Managment.

CONTRAINDICATIONS

    - Volume depletion or hypotension.
    - Head trauma.
    - Acute asthma.
    - Known hypersensitivity to MS.

WARNINGS

    Morphine is detoxified by the liver. It is potentiated by alcohol, antihistamines, barbiturates, sedatives and beta blockers.

SIDE EFFECTS

    CNS:Euphoria, drowsiness, papillary constriction, respiratory arrest.
    Cardiovascular: Bradycardia, hypotension.

    GI:Decreases gastric motility, nausea and vomiting.

    GU:Urinary retention.

    Respiratory:Bronchoconstriction, decrease cough reflex.

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