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Labetalol

Labetalol Hydrochloride
(Normodyne®, Trandate®)

CLASS

Sympathetic blocker
Alpha-adrenergic blocker, Beta-adrenergic blocker

DOSAGE

    Adult: 20 mg slow (over 2 minutes) IV.

ACTIONS

    Labetalol combines both selective, competitive alpha1-adrenergic blocking and nonselective, competitive beta-adrenergic blocking activity in a single substance. These actions decrease blood pressure without reflex tachycardia and without a significant reduction in heart rate.

INDICATIONS

    Control of blood pressure in severe hypertension.

CONTRAINDICATIONS

    - Bronchial asthma.
    - Overt cardiac failure.
    - Greater than first degree heart block.
    - Cardiogenic shock.
    - Severe bradycardia.

WARNINGS

Use caution with patients that have a medical history of: liver problems, heart problems (e.g., mild/moderate congestive heart failure), lung disease (chronic bronchitis, emphysema), pheochromocytoma, diabetes, any allergies.

Blood pressure, pulse, and EKG must be constantly monitored. Atropine and transcutaneous pacing should be available.

SIDE EFFECTS

    Cardiovascular:Symptomatic postural hypotension, ventricular dysrhythmia, and rarely syncope, bradycardia, and heart block.

    CNS:Dizziness, tingling of the scalp/skin, numbness, vertigo, etc.

    Respiratory:Wheezing, bronchospasm.

    GI:Nausea / vomiting, etc.

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