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Glucagon

Glucagon
(Glucagen®)

CLASS

Pancreatic hormone, Insulin antagonist
Glucose elevating agent

DOSAGE

    Adult:0.5 to 1.0 unit (or 0.5-1.0 mg) of Glucagon IM (or IV).
    This can be repeated twice.

    Pediatric:
    For patients less than 20kg- 0.02mg/kg IM (Not as effective in children).

For patients over 20kgs - 1mg IM

NOTE: For Beta blocker overdose give 0.5mg IVP/IM/IOP an repeated as needed until symptoms are gone.
May require very high IV doses for Beta blocker overdose (5-10 mg IV).

ACTIONS

    Glucagen produced in the pancreas by the Alpha cells of the Islets of Langerhans, causes an increase in blood glucose concentrations. It is effective in small doses and no evidence of toxicity has been reported with its use. Glucagon acts only on liver glycogen, converting it to glucose, if patient has adequate glycogen reserves. Also, possesses positive inotropic and chronotropic properties.

INDICATIONS

    - Glucagon is indicated for the treatment of hypoglycemia when an IV cannot be established and oral glucose is contraindicated.
    - Possibly effective in symptomatic beta blocker overdose.

CONTRAINDICATIONS

    Since glucagon is a protein, hypersensitivity is a possibility.

WARNINGS

    Glucagon should be administered with caution in patients with a history of insulinoma and/or pheochromocytoma.

SIDE EFFECTS

    Occasional nausea and vomiting.

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