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Plavix

CLOPIDOGREL BISULFATE
Plavix

CLASSIFICATION

Anti-platelet drug
Thienopyridine class inhibitor of P2Y12 ADP platelet receptors

DOSAGE

    (or IV).

ACTIONS

    Plavix has an anti-platelet effect that inhibits the ability of platelets to clump together as part of a blood clot.

    It is an inhibitor of adenosine diphosphate (ADP) induced platelet aggregation acting by direct inhibition of ADP binding to its receptor and of the subsequent ADP-mediated activation of glycoprotein GPIIb/IIIa complex.

INDICATIONS

    Clopidogrel is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack, unstable angina), recent stroke, or blood circulation disease (peripheral vascular disease).

CONTRAINDICATIONS

    - Hypersensitivity to the drug substance
    - Active pathological bleeding; peptic ulcer or intracranial hemorrhage

WARNINGS

    Consult with physician if patient has a history of:
    -blood disorders (e.g., hemophilia),
    - bleeding conditions (e.g., active peptic ulcers).
    - recent surgery
    - recent serious injury (physical trauma)
    - severe liver disease, severe kidney disease
    - history of abnormal bleeding, other conditions that may put then at high risk for bleeding (e.g., certain stomach/abdominal problems, certain eye diseases)

SIDE EFFECTS

    Common side effects are easy bruising; minor bleeding

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